St. John's Wort There are several studies that show St. John's wort is more effective than placebo and as effective as older antidepressants called tricyclics in the short-term treatment of mild or moderate depression. Other studies show St. John's wort is as effective as selective SSRI antidepressants such as Prozac or Zoloft in treating depression. St John's wort is usually well tolerated. The most common side effects are stomach upset, skin reactions, and fatigue. SAM-e It

St. John's Wort There are several studies that show St. John's wort is more effective than placebo and as effective as older antidepressants called tricyclics in the short-term treatment of mild or moderate depression. Other studies show St. John's wort is as effective as selective SSRI antidepressants such as Prozac or Zoloft in treating depression. St John's wort is usually well tolerated. The most common side effects are stomach upset, skin reactions, and fatigue. SAM-e It